Generally drug therapy for OSA has had little evidence or pathophysiological leads for successful interventions. This study, albeit using the weight loss route with AHI end points, has shown good effect and warrants attention as far as treatment for overweight OSA goes.
http://www.ncbi.nlm.nih.gov/pubmed/23115402
http://www.ncbi.nlm.nih.gov/pubmed/23115402
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